Cu Oac 2 Catalyzed Oxidative Coupling Of Imidazo 1 2 A Pyridines
![cu oac 2 catalyzed Aerobic oxidative Dehydrogenation 55 Off cu oac 2 catalyzed Aerobic oxidative Dehydrogenation 55 Off](https://pubs.acs.org/cms/10.1021/acs.joc.6b02644/asset/images/large/jo-2016-02644d_0002.jpeg)
Cu Oac 2 Catalyzed Aerobic Oxidative Dehydrogenation 55 Off Cu(oac) 2 –et 3 n mediated oxidative coupling of α azido ketones with pyridinium ylides: utilizing in situ generated imines for regioselective synthesis of imidazo[1,2 a]pyridines. chemical communications 2015 , 51 (52) , 10475 10478. A facile method for direct pd(oac) 2 catalyzed oxidative cross coupling of unactivated imidazo[1,2 a]pyridine with simple arenes has been developed. the reaction shows good reaction efficiency, high regioselectivity, and good functional group compatibility.
![cu oac 2вђђcatalysed oxidative Dual Cвђ H Nвђ H Activation Of Terminal cu oac 2вђђcatalysed oxidative Dual Cвђ H Nвђ H Activation Of Terminal](https://chemistry-europe.onlinelibrary.wiley.com/cms/asset/971cbf3b-a096-41a3-8963-450689c4c68b/mfig000.jpg?trick=1658190504645)
Cu Oac 2вђђcatalysed Oxidative Dual Cвђ H Nвђ H Activation Of Terminal Il kcc 1 catalyzed synthesis of imidazo[1,2 a]pyridines 64 in good to excellent yields from the one pot reaction of 2 aminopyridine 12 , phenyl acetylene 63 , and aromatic alde. To the best of our knowledge, imidazo[1,2 a]pyridines can be synthesized from 2 aminopyridines, terminal alkyne and aldehyde in. three component coupling reaction, catalyzed by copper, in one pot (scheme 1b).19 however, aldehydes are unstable and easily oxidized. they are environmentally unfriendly for synthesis or complex procedures. An efficient and mild condition for synthesis of imidazo[1,2 a]pyridines 1.33 and 1.35 via bf 3 ·et 2 o—catalyzed oxidative coupling of 2 aminopyridines 1.23 with β ketoesters 1.32 and 1,3 diones 1.34 in the presence of phi(oac) 2 as an oxidant has been reported by yu and co workers. Phenacyl azides were reacted with pyridinium ylides in the presence of cu(oac)2 (2 mol%) and et3n utilizing molecular oxygen as a green oxidant to yield imidazo[1,2 a]pyridines in exclusive regioselectivity. following the optimized protocol, 28 different fused heterocycles were synthesized in high yields (71.
![cu Oac 2 Catalyzed Oxidative Coupling Of Imidazo 1 2 A Pyridines 36 cu Oac 2 Catalyzed Oxidative Coupling Of Imidazo 1 2 A Pyridines 36](https://www.researchgate.net/publication/328201398/figure/fig12/AS:963460724707362@1606718345473/CuOAc2-catalyzed-oxidative-coupling-of-imidazo1-2-apyridines-36-with-thiols-37.png)
Cu Oac 2 Catalyzed Oxidative Coupling Of Imidazo 1 2 A Pyridines 36 An efficient and mild condition for synthesis of imidazo[1,2 a]pyridines 1.33 and 1.35 via bf 3 ·et 2 o—catalyzed oxidative coupling of 2 aminopyridines 1.23 with β ketoesters 1.32 and 1,3 diones 1.34 in the presence of phi(oac) 2 as an oxidant has been reported by yu and co workers. Phenacyl azides were reacted with pyridinium ylides in the presence of cu(oac)2 (2 mol%) and et3n utilizing molecular oxygen as a green oxidant to yield imidazo[1,2 a]pyridines in exclusive regioselectivity. following the optimized protocol, 28 different fused heterocycles were synthesized in high yields (71. Phenacyl azides were reacted with pyridinium ylides in the presence of cu(oac)2 (2 mol%) and et3n utilizing molecular oxygen as a green oxidant to yield imidazo[1,2 a]pyridines in exclusive regioselectivity. following the optimized protocol, 28 different fused heterocycles were synthesized in high y …. α diazoketones undergo smooth coupling with 2 aminopyridines in the presence of 10 mol % of copper(ii) triflate to produce the corresponding 2 substituted imidazo[1,2 a]pyridines (ips) in excellent yields with high selectivity. rh 2 (oac) 4 is also found to be an equally effective catalyst for this transformation.
![cu oac 2 catalyzed Intramolecular oxidative Cyclization Of Substituted cu oac 2 catalyzed Intramolecular oxidative Cyclization Of Substituted](https://www.researchgate.net/publication/334637198/figure/fig4/AS:963460833759264@1606718371517/Plausible-mechanism-of-ironIII-catalyzed-intramolecular-cyclization-to-form_Q640.jpg)
Cu Oac 2 Catalyzed Intramolecular Oxidative Cyclization Of Substituted Phenacyl azides were reacted with pyridinium ylides in the presence of cu(oac)2 (2 mol%) and et3n utilizing molecular oxygen as a green oxidant to yield imidazo[1,2 a]pyridines in exclusive regioselectivity. following the optimized protocol, 28 different fused heterocycles were synthesized in high y …. α diazoketones undergo smooth coupling with 2 aminopyridines in the presence of 10 mol % of copper(ii) triflate to produce the corresponding 2 substituted imidazo[1,2 a]pyridines (ips) in excellent yields with high selectivity. rh 2 (oac) 4 is also found to be an equally effective catalyst for this transformation.
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