Hierarchy And Plasticity In The Intestinal Stem Cell Compartment

Hierarchy And Plasticity In The Intestinal Stem Cell Compartment Parallel with this evidence, recent studies have revealed considerable plasticity within the intestinal stem cell (isc) compartment. we discuss the evidence for plasticity and hierarchy within the isc compartment and how these properties govern tissue regeneration and contribute to oncogenic transformation leading to colorectal cancers. Model of intestinal stem cell (isc) compartment organization. in the hierarchical model, a population of rare stem cells that lack canonical wnt pathway activity and reside in the quiescent g0 state sits atop the hierarchy. during homeostasis these cells periodically divide to generate crypt base columnar stem cells (cbcs) driven by high wnt.

Hierarchy And Plasticity In The Intestinal Stem Cell Compartment Hierarchy and plasticity in the intestinal stem cell compartment. maryam yousefi,1 linheng li,2,3,* and christopher j. lengner1,*. somatic stem cells maintain tissue homeostasis by organizing themselves in such a way that they can maintain proliferative output while simultaneously protecting themselves from dna damage that may lead to oncogenic. A well characterized example of cellular plasticity in normal cells is the intestinal stem cell population [19], in which certain differentiated endocrine cells modulate their genetic profiles to. Altogether, these data provide compelling evidence that plasticity of various committed progenitors, and their ability to revert to a stem cell like identity, is a key mechanism by which the intestinal epithelium copes with experimental challenges that damage the stem cell compartment. moreover, it also reinforces the notion that the intestinal. Complicating the traditional views of a stem cell hierarchy is the recent evidence that lineage‐committed progenitors possess a level of plasticity allowing them to revert to a stem cell state. in the intestine, this plasticity has been demonstrated by lineage‐tracing of ‘committed cells’ (van es et al. 2012; buczacki et al.