Dna damage response (ddr) is critical to ensure genome stability, and defects in this signaling pathway are highly associated with carcinogenesis and tumor progression. nevertheless, this also provides therapeutic opportunities, as cells with defective ddr signaling are directed to rely on compensatory survival pathways, and these vulnerabilities have been exploited for anticancer treatments. Platinum based chemotherapies, such as cisplatin, play a large role in cancer treatment. the development of resistance and treatment toxicity creates substantial barriers to disease control, yet. to enhance the therapeutic index of cisplatin based chemotherapy, it is imperative to circumvent resistance and toxicity while optimizing tumor sensitization. one of the primary mechanisms by which.
Over the course of long term evolution, cells have developed intricate defense mechanisms in response to dna damage; these mechanisms play a pivotal role in maintaining genomic stability. defects in the dna damage response pathways can give rise to various diseases, including cancer. the dna damage response (ddr) system is instrumental in safeguarding genomic stability. the accumulation of dna. Yi sun. signal transduction and targeted therapy (2024) cells have evolved a complex network of biochemical pathways, collectively known as the dna damage response (ddr), to prevent detrimental. To adequately repair dna insults that continuously threaten genome integrity, cells have developed multiple mechanisms, collectively referred to as the ‘dna damage response’ (ddr), which. Dna double strand breaks are the most lethal lesions induced by ionizing radiation and can trigger a series of cellular dna damage responses (ddrs), including those helping cells recover from.
To adequately repair dna insults that continuously threaten genome integrity, cells have developed multiple mechanisms, collectively referred to as the ‘dna damage response’ (ddr), which. Dna double strand breaks are the most lethal lesions induced by ionizing radiation and can trigger a series of cellular dna damage responses (ddrs), including those helping cells recover from. Deficiency in dna damage response (ddr) genes leads to impaired dna repair functions that will induce genomic instability and facilitate cancer development. however, alterations of ddr genes can serve as biomarkers for the selection of suitable patients to receive specific therapeutics, such as immune checkpoint blockade (icb) therapy. in addition, certain altered ddr genes can be ideal. An underlying hallmark of cancers is their genomic instability, which is associated with a greater propensity to accumulate dna damage. historical treatment of cancer by radiotherapy and dna damaging chemotherapy is based on this principle, yet it is accompanied by significant collateral damage to normal tissue and unwanted side effects. targeted therapy based on inhibiting the dna damage.
Deficiency in dna damage response (ddr) genes leads to impaired dna repair functions that will induce genomic instability and facilitate cancer development. however, alterations of ddr genes can serve as biomarkers for the selection of suitable patients to receive specific therapeutics, such as immune checkpoint blockade (icb) therapy. in addition, certain altered ddr genes can be ideal. An underlying hallmark of cancers is their genomic instability, which is associated with a greater propensity to accumulate dna damage. historical treatment of cancer by radiotherapy and dna damaging chemotherapy is based on this principle, yet it is accompanied by significant collateral damage to normal tissue and unwanted side effects. targeted therapy based on inhibiting the dna damage.
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