The cyclopentane peramivir (bcx 1812, rwj 270201) is a highly selective inhibitor of influenza a and b virus neuraminidases and a potent inhibitor of influenza a and b virus replication in cell culture. the in vitro potency appears to be greater than either zanamivir or oseltamivir carboxylate based on the generally lower ec (50) values seen. Stereoselective total synthesis of racemic bcx 1812 (rwj 270201) for the development of neuraminidase inhibitors as anti influenza agents. the journal of organic chemistry 2003 , 68 (17) , 6591 6596.
In mice infected with influenza a or b viruses, oral treatment with peramivir was highly effective in preventing death, signs of the disease and in lowering lung virus titres; similar effects were seen in influenza a virus infected ferrets. the cyclopentane peramivir (bcx 1812, rwj 270201) is a highly selective inhibitor of influenza a and b virus neuraminidases and a potent inhibitor of. Rwj 270201 is a unique na inhibitor with a cyclopentane ring structure and high selectivity for the influenza na. rwj 270201 has efficacy comparable to or better than earlier na inhibitors against a wide range of influenza a and b isolates, including recently emerged and avian strains, both in vitro and in a lethal murine model of influenza. The cyclopentane peramivir (bcx 1812, rwj 270201) is a highly selective inhibitor of influenza a and b virus neuraminidases and a potent inhibitor of influenza a and b virus replication in cell culture. Bcx 1812 (rwj 270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure based drug design j med chem . 2000 sep 21;43(19):3482 6. doi: 10.1021 jm0002679.
The cyclopentane peramivir (bcx 1812, rwj 270201) is a highly selective inhibitor of influenza a and b virus neuraminidases and a potent inhibitor of influenza a and b virus replication in cell culture. Bcx 1812 (rwj 270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure based drug design j med chem . 2000 sep 21;43(19):3482 6. doi: 10.1021 jm0002679. This website requires cookies, and the limited processing of your personal data in order to function. by using the site you are agreeing to this as outlined in our privacy notice and cookie policy. The de guanidinylated derivative of peramivir remains a potent inhibitor of influenza neuraminidase. bromba cm, mason jw, brant mg, chan t, lunke md, petric m, boulanger mj, wulff je. bioorg med chem lett, 21(23):7137 7141, 24 sep 2011 cited by: 6 articles | pmid: 22001088.
This website requires cookies, and the limited processing of your personal data in order to function. by using the site you are agreeing to this as outlined in our privacy notice and cookie policy. The de guanidinylated derivative of peramivir remains a potent inhibitor of influenza neuraminidase. bromba cm, mason jw, brant mg, chan t, lunke md, petric m, boulanger mj, wulff je. bioorg med chem lett, 21(23):7137 7141, 24 sep 2011 cited by: 6 articles | pmid: 22001088.
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