Pdf Pharmacodynamic Evaluation Of Rwj 270201 A Novel Neuraminidase Pharmacodynamic evaluation of rwj 270201, a novel neuraminidase inhibitor, in a lethal murine model of influenza predicts efficacy for once daily dosing antimicrob agents chemother . 2001 jul;45(7):2115 8. doi: 10.1128 aac.45.7.2115 2118.2001. Pharmacodynamic evaluation of rwj 270201, a novel neuraminidase inhibitor, in a lethal murine model of influenza predicts efficacy for once daily dosing g. l. drusano , 1, * s. l. preston , 1 d. smee , 2 k. bush , 3 k. bailey , 2 and r. w. sidwell 2.
Molecules Free Full Text Screening For Neuraminidase Inhibitory Pharmacodynamic evaluation of rwj 270201, a novel neuraminidase inhibitor, in a lethal murine model of influenza predicts efficacy for once daily dosing g. l. drusano,1* s. l. preston,1 d. smee,2 k. bush,3 k. bailey2, and r. w. sidwell2 division of clinical pharmacology, clinical research initiative, albany medical college, albany, new york,1. Abstract we examined rwj 270201 in a lethal model of influenza in balb c mice. the aim was to delineate the pharmacodynamically linked variable for the drug. challenge was performed with influenza virus a shongdong 09 93 (h3n2). treatment. We examined rwj 270201 in a lethal model of influenza in balb c mice. the aim was to delineate the pharmacodynamically linked variable for the drug. challenge was performed with influenza virus a shongdong 09 93 (h3n2). treatment was administered by gavage. five doses (1 to 10 mg kg of body weight) and three schedules (every 24, 12, and 8 h. It is concluded that once daily dosing of rwj 270201 should be evaluated in clinical trials of influenza therapy because of its anti influenza effect, which is independent of schedule. abstract we examined rwj 270201 in a lethal model of influenza in balb c mice. the aim was to delineate the pharmacodynamically linked variable for the drug. challenge was performed with influenza virus a.
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