Hierarchy And Plasticity In The Intestinal Stem Cell Compartment The intestinal epithelium is the fastest renewing tissue in mammals and has a large flexibility to adapt to different types of damage. lgr5 crypt base columnar (cbc) cells act as stem cells during homeostasis and are essential during regeneration. upon perturbation, the activity of cbcs is dynamically regulated to maintain homeostasis and. Intestinal stem cells are found at the base of the crypt; neighboring niche cells include paneth cells, telocytes, pdgfra low, and cd34 fibroblasts. iscs receive paracrine growth factors from the.
Cellular Plasticity In Intestinal Homeostasis And Disease Cell Stem ођ The epithelium of the small intestine is composed of a monolayer of different cell types that form serial arrays of luminal projections (villi) and cup shaped invaginations (crypts). the homeostatic constant regeneration of the intestinal epithelium is driven by active lgr5 stem cells (active intestinal stem cells [iscs]) at the crypt bases. Emerging evidence supports a dynamic model of the intestine, where the epithelium can de differentiate and function as an alternative source of stem cells upon tissue damage and stress. de sousa e melo and de sauvage discuss the mechanistic principles and key players involved in intestinal plasticity as well as potential therapeutic implications of cellular plasticity in regenerative medicine. The intestinal epithelium is a rapidly renewing cellular compartment. this constant regeneration is a hallmark of intestinal homeostasis and requires a tightly regulated balance between intestinal stem cell (isc) proliferation and differentiation. since intestinal epithelial cells directly contact pathogenic environmental factors that continuously challenge their integrity, iscs must also. The intestinal epithelium is a rapidly renewing cellular compartment. this constant regeneration is a hallmark of intestinal homeostasis and requires a tightly regulated balance between intestinal stem cell (isc) proliferation and differentiation. since intestinal epithelial cells directly contact pathogenic environmental factors that continuously challenge their integrity, iscs must also.
Regulation And Plasticity Of Intestinal Stem Cells During Homeostasis The intestinal epithelium is a rapidly renewing cellular compartment. this constant regeneration is a hallmark of intestinal homeostasis and requires a tightly regulated balance between intestinal stem cell (isc) proliferation and differentiation. since intestinal epithelial cells directly contact pathogenic environmental factors that continuously challenge their integrity, iscs must also. The intestinal epithelium is a rapidly renewing cellular compartment. this constant regeneration is a hallmark of intestinal homeostasis and requires a tightly regulated balance between intestinal stem cell (isc) proliferation and differentiation. since intestinal epithelial cells directly contact pathogenic environmental factors that continuously challenge their integrity, iscs must also. Appropriate control of iscs and other populations of intestinal epithelial cells with stem cell activity is essential for intestinal homeostasis and regeneration while their deregulation is implicated in colorectal tumorigenesis. in this review, we will summarize the recent findings about isc identity and cellular plasticity in intestine. These cascades ultimately govern tf expression to promote early cell lineage decisions in both crypt stem cells and progenitors. highlighting recent studies investigating signaling, transcriptional, and epigenetic mechanisms of intestinal epithelial cells, we will discuss the mechanisms underlying crypt homeostasis, plasticity, and niches.
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