Shifting The Focus вђ The Primary Role Of Ilвђђ23 In Psoriasis And Other
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The most recent evidence suggests that il 23 might be an even more potent target for the effective treatment of psoriasis and other autoimmune inflammatory disorders. this review will describe recent developments leading to the current understanding of the key role of il 23 as a 'master regulator' of autoimmune inflammation and the clinical. Current model of the pathophysiology of psoriasis. il ‐23 bridges the innate and adaptive immune responses and plays a key role in inducing th17 cell differentiation. the resulting elevated il ‐17 secretion maintains the pathological response of keratinocytes, resulting in psoriatic plaque formation.
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Review article shifting the focus – the primary role of il 23 in psoriasis and other inflammatory disorders m.j. gooderham,1,* k.a. papp,2 c.w. lynde3,4 1skin centre for dermatology, probity. Abstract insights into the pathophysiology of autoimmune inflammatory diseases including psoriasis have advanced considerably in recent years, and in parallel, so too have the available treatment o. Shifting the focus: the primary role of il 23 in psoriasis and other inflammatory disorders journal of the european academy of dermatology and venereology united states doi 10.1111 jdv.14868. This review will describe recent developments leading to the current understanding of the key role of il 23 as a ‘master regulator’ of autoimmune inflammation and the clinical evidence for agents that specifically target this modulator in the context of treating psoriasis, spondyloarthropathy and inflammatory bowel disease.
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Shifting the focus: the primary role of il 23 in psoriasis and other inflammatory disorders journal of the european academy of dermatology and venereology united states doi 10.1111 jdv.14868. This review will describe recent developments leading to the current understanding of the key role of il 23 as a ‘master regulator’ of autoimmune inflammation and the clinical evidence for agents that specifically target this modulator in the context of treating psoriasis, spondyloarthropathy and inflammatory bowel disease. The vast majority of available genetic association studies highlight the role of the immune system in the pathophysiology of psoriasis. even if some other genes such as il 36 receptor antagonist (il 36rn) are implicated (31, 32), the il 17 23 axis seems to play a cardinal role. il17 as a central effector in psoriasis. The il 23 il 17 axis is currently considered to be crucial in the pathogenesis of psoriasis. human il 23 is primarily produced by antigen presenting cells and induces and maintains differentiation of th17 cells and th22 cells, a primary cellular source of proinflammatory cytokines such as il 17 and il 22, which mediate the epidermal hyperplasia.
![](https://i0.wp.com/sicepat.com/images/image-not-found.png)
The vast majority of available genetic association studies highlight the role of the immune system in the pathophysiology of psoriasis. even if some other genes such as il 36 receptor antagonist (il 36rn) are implicated (31, 32), the il 17 23 axis seems to play a cardinal role. il17 as a central effector in psoriasis. The il 23 il 17 axis is currently considered to be crucial in the pathogenesis of psoriasis. human il 23 is primarily produced by antigen presenting cells and induces and maintains differentiation of th17 cells and th22 cells, a primary cellular source of proinflammatory cytokines such as il 17 and il 22, which mediate the epidermal hyperplasia.
![](https://i0.wp.com/sicepat.com/images/image-not-found.png)
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