Multiple Tense Vesiculobullous Lesions On The Bilateral Dorsal Hands Specialty. dermatology. a vesiculobullous disease is a type of mucocutaneous disease characterized by vesicles and bullae (i.e. blisters). both vesicles and bullae are fluid filled lesions, and they are distinguished by size (vesicles being less than 5–10 mm and bulla being larger than 5–10 mm, depending upon which definition is used). A blistering disease is a condition in which there are fluid filled skin lesions. vesicles are small blisters less than 5 mm in diameter. a bulla is a larger blister. note that the plural of bulla is bullae. blisters may break or the roof of the blister may become detached forming an erosion. exudation of serous fluid forms crust.
Vesicular And Bullous Disease There are many dermatological conditions that can lead to the development of blisters. in some of these conditions, eg the immunobullous disorders, the blisters are the primary feature, in others, eg leg oedema, the blisters are secondary to an underlying condition. this chapter provides an overview of vesicular and bullous disorders, with an aim to help in the diagnosis. (see "vesicular, pustular, and bullous lesions in the newborn and infant".) definition blistering skin disorders are characterized by the presence of fluid filled lesions on the skin that occur as a result of a loss of adhesion between cells within the epidermis ( acantholysis ), edema between epidermal cells ( spongiosis ), or disassociation. A diverse range of inflammatory dermatoses are characterized by vesicles or bullae. vesiculobullous diseases can be associated with significant morbidity and mortality rates that necessitate their early clinical recognition and prompt management. while the diagnosis and management of vesiculobullous dermatoses may appear daunting to clinicians. Berger tg, james wd, elston dm. andrew's diseases of the skin, clinical dermatology, 10th edition. wb saunders; 2008. these signs serve to demonstrate that in some diseases (e.g., pemphigus vulgaris and bullous pemphigoid) the extent of blistering is greater than observed by inspection. subepidermal bullae are tense.
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