P38α mitogen activated protein kinase (mapk) is an important molecular switch involved in the regulation of many pathways, such as pro inflammatory signaling. P38α mitogen activated protein kinase (mapk) is an important molecular switch involved in the regulation of many pathways, such as pro inflammatory.
During the last two decades, many p38α mitogen activated protein kinase (p38α mapk) inhibitors have been developed and tested in preclinical clinical studies for the treatment of various disorders, especially problems with the origin of inflammation. previous studies strongly suggest the involvement of the p38α mapk pathway in the pathogenesis of neurodegenerative disorders. despite the. Recently, structure based studies of large make on demand virtual libraries with hundreds of millions, and even billions of compounds have successfully led to the discovery of novel scaffolds with. The discovery of selective and potent inhibitors of p38 mapks has aided the understanding of their role in signal transduction and the regulation of a multitude of cellular responses. p38α mapk. With the ever increasing number of synthesis on demand compounds for drug lead discovery, there is a great need for efficient search technologies. we present the successful application of a.
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